The emergence of the importance of such phenomena as alternative RNA processing, regulatory RNAs, and RNA-mediated enzymatic mechanisms to the regulation of gene expression in cells, along with the recognition of the contributions of RNA to disease pathogenesis and normal development, have made an understanding of the field of RNA biology essential to all life science disciplines. It is the goal of WIREs RNA to provide comprehensive, up-to-date, and coherent coverage of this interesting and growing field, providing a framework for both RNA experts and interdisciplinary researchers to not only gain perspective in areas of RNA biology, but to generate new insights and applications as well. Major topics to be covered are: RNA Structure and Dynamics; RNA Evolution and Genomics; RNA-Based Catalysis; RNA Interactions with Proteins and Other Molecules; Translation; RNA Processing; RNA Export/Localization; RNA Turnover and Surveillance; Regulatory RNAs/RNAi/Riboswitches; RNA in Disease and Development; and RNA Methods.